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Nature 414:821821 Adib M, Peytam F, Rahmanian-Jazi M, Mahernia S, Bijanzadeh HR, Jahani M, Mohammadi-Khanaposhtani M, Imanparast S, Faramarzi MA, Mahdavi M (2018) New 6-amino-pyrido [2,3-d] pyrimidine-2,4-diones as novel agents to treat type 2 diabetes: a simple and efficient synthesis, alpha-glucosidase inhibition, molecular modeling and kinetic study