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10.1016/j.phymed.2021.153519

Interestingly, ferrostatin-1, but not necroptosis-targeting agents, was capable of preserving the renal function of the mice in the study, regardless of the upregulation of the necroptosis markers MLKL and RIPK3 in the kidney

In the myocardial ischemia/reperfusion model in vivo, EGCG preconditioning significantly decreased the levels of creatine kinase MB isoform and lactate dehydrogenase, increased the ATP levels, suppressed apoptosis, and partially preserved heart function [212]

Salo JM, Kedves O, Mikkola R, Kredics L, Andersson MA, Kurnitski J, et al

These parameters need to be established initially through small scale exploratory studies, and then sufficient data must be accumulated to permit multidimensional analysis