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SGLT2 inhibitors have limited glucose-lowering efficacy in individuals with an estimated glomerular filtration rate (eGFR) 9.0%)
In the brain, where neurons have limited capacity to break down FFAs, lipids are continuously shuttled to astrocytes via ApoE [43]

Oculomotor fatigue and neuropsychological assessments mirror multiple sclerosis fatigue


An increase in the renal production of ammonia could be another factor that contributes to the development of hyperammonaemia in VPA-treated patients