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TPX2 promotes ferroptosis in LPS-induced C28/I2 chondrocytes via NF-B p65-mediated downregulation of GPX4 and SLC7A11

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Within endosome compartments, Fe 3+ is reduced to ferrous iron (Fe 2+ ) and released into a labile iron pool in the cytoplasm via the divalent metal transporter 1 (DMT1) ( Figure 5 )