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The FDA is unequivocal that "retatrutide and cagrilintide cannot be used in compounding under federal law." "These are not components of FDA-approved drugs and have not been found safe and effective for any condition," the agency said in drug safety information posted online

Additionally, two-year safety data from the STEP 5 trial shows that while gastrointestinal events occurred in 82% of participants at some point during the study, most of these events were concentrated in the initial 6 months, with frequency and severity declining markedly in long-term treatment

[DOI] [PubMed] [Google Scholar] 26.Anaf V, Simon Ph, Fayt I, et al

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Preclinical research has explored its interaction with cellular signaling pathways involved in vascular and inflammatory responses