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When iron-laden transferrin binds to TfR on the cell surface, the resulting complex (TFRC) undergoes clathrin-mediated internalization into endosomes (Figure 3)

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It is widely utilized in formulations for anti-aging skincare and haircare products, as well as general beauty products and cosmeceuticals (e.g., creams, lotions, serums, masks) [18,34]

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