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Most peptides are remarkably stable in their lyophilized powder form

Protection for the Phosphate Group in Greene's Protective Groups in Organic Synthesis

Ketamine (Ketalar) is a drug with wide ranging effects on the central nervous system due to its inhibition of glutamate receptors, known as N-methyl-D-aspartate (NMDA) receptors, in the brain

The authors research whether TB-500 may tone down this signaling and suggest that the peptide may increase the level of miR-146a, a small regulatory RNA molecule whose role may be to act as an internal brake on inflammatory signaling pathways

Despite the challenges involved in this transformation, the potential for improving patient care is considerable, as this condition has long been inadequately treated