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The molecular mechanisms underlying 5-amino-1MQ's anti-adipogenic effects involve complex interactions between NAD+ metabolism, methylation status, and transcriptional regulation

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By genetically deleting the disulfide reductase pathways from mouse liver, we uncovered an inducible, ubiquitous, cell-autonomous reductase-independent backup pathway for the generation of cysteine, driven by cystine CS bond cleavage.