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Similar to the effects of NNMT overexpression, hepatocytes treated with MNAM exhibited significant increases in glucose production and expression of Sirt1, G6pc, and Pck1

We next wanted to investigate the contributions of IMSlocalized redox processes to E GSH [IMS] including the respiratory chain, antioxidative systems and the Erv1Mia40 machinery for protein oxidation (Figure 5C)

Omission of N-acetylcysteine sensitises PMDOs to oxaliplatin We next assessed whether glutathione synthesis could modulate PMDO resistance to oxaliplatin

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If cholesterol hypersecretion occurs, the gallbladder bile will become consistently supersaturated with cholesterol [23], a potent condition predisposing to precipitation and aggregation of cholesterol crystals [24]