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doi: 10.1172/JCI99490 83 ZhaiJXZhangZXFengYJDingSSWangXHZouLWet al

This translocation of gut luminal pathobionts and products triggers inflammatory responses in the liver, involving resident hepatic macrophages, Kupffer cells, and other infiltrating immune cells that activates hepatic stellate cells (HSC), causing aberrant production of extracellular matrix (ECM) proteins and fibrosis development

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Similar content being viewed by others Introduction Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, which arises from impaired insulin secretion, diminished insulin action, or a combination of both mechanisms 1

For supplemental reading about optimizing endpoint quality in rare disease trials, visit this blog: 5 Tips for Success in Rare Disease Studies - Signant Health Adolescent schizophrenia Adolescent schizophrenia trials face significant challenges, particularly due to the lack of validated assessment tools tailored to this demographic