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Glutathionylation regulates IkappaB

The resulting acetoxyarylamines are highly unstable, spontaneously forming arylnitrenium ions that bind to DNA (Bland & Kadlubar, 1985) and ultimately lead to mutagenesis and carcinogenesis (Kerdar et al., 1993)
Tognetti VB, Bielach A, Hrtyan M

The risk of nephropathy increases in cases of type 2 diabetes that carry common variants of CNDP1 and CNDP2 genes [132]
