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[49] ERK 1 and 2 are activated via the Raf-Ras-MEK1/2 pathway induced by mitogenic stimuli such as epidermal growth factor, [50] whereas the JNK and p38 MAPK are activated by the MAPK kinase, activated themselves by the TGF--activated kinase-1 (TAK1) upon stress stimuli

[DOI] [PubMed] [Google Scholar] 272.Greaves, L

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Before 2013s breakthrough clinical proof, it was understood that the bodys protection from toxicity was borne mainly by the liver, and that the depletion of glutathione contributed to that organs functional decline