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J Epidemiol Glob Health 14(3):561579

This is probably related to higher level of mycophenolic acid resulting from drug interaction with tacrolimus

Its strong water solubility, easy blood-brain barrier passage, high bioavailability (8195%), long half-life of approximately 1925 h, and occasional adverse reactions, like tiredness, anorexia, upper respiratory tract infections, nausea, diarrhea, cognitive impairment (difficulty remembering things, poor concentration, etc.), and weight loss, are some of its beneficial properties

Glutathione S-Transferase T1 (GSTT1) null polymorphism, smoking, and their interaction in coronary heart disease: a comprehensive meta-analysis

Contrary to previous assumptions, emerging research shows that the cumulative dosage of methotrexate may not be the only factor influencing chronic hepatotoxicity