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J Thorac Oncol 9(7):998-1007, 2014

By way of confirmation of these structural assignments, orthologues of 7 were synthesized by the oxidative glutathionylation of feruloyltyramine

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Conversely, in pathological or stress conditions, ROS overwhelms antioxidant systems leading to an imbalance, which, in turn, causes oxidative stress and irreversible changes in cell compounds, including proteins, carbohydrates and lipids, in addition to being able to disrupt normal cellular-signaling mechanisms (Zal et al., 2014

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