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Recent strategies to overcome these hurdles include the development of novel delivery systems such as gene-nanocarrier complexes, the use of human induced pluripotent stem cell-derived neural progenitor cells secreting GDNF (iNPC-GDNFs) for combined cell and gene therapy, and the exploration of small neurotrophic peptides like djGDNF47 generated via alternative splicing (Shamadykova et al., 2025

Srikanth K, Kumar H, Park W, Byun M, Lim D, Kemp S, et al

Individual response, diagnosis, and prescriber assessment determine which is appropriate

The following Table summarizes the uses of ST in rheumatology
