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Our detailed analysis of data from recent scRNA-seq studies of dorsal pons 87 and LC cells 88 is shown in Fig

[106] reported that naloxone is capable of blocking norepinephrine-induced antinociception

Moreover, in comparison with the placebo, a significant improvement in cognitive functions and other neurological parameters was observed in the treatment group, warranting further investigation in larger cohorts

10.1016/j.pbb.2009.03.012 96.Wacker J , Reuter M , Hennig J , Stemmler G

Iron-induced formation of ROS causes oxidation and oligomerization of Tom20, leading to the recruitment of Bax and subsequent cytochrome c release and caspase-3 activation
