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In patients with NAFLD, higher levels of insulin, blood pressure, serum triglycerides, total cholesterol, and liver enzymes were observed [43]

In summary, evidence on DHA and cardiovascular outcomes in adults is largely derived from high-income countries, with only four studies from upper-middle-income settings and no data from low- or lower-middle-income countries

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41 As well as genomic instability, the aging process is characterized by changes to DNA methylation patterns known as epigenetic drift, which ultimately alters gene expression

Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)