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Interestingly, ursodeoxycholic acid (UDCA), the only medication approved by the FDA for the treatment of primary biliary cirrhosis [152], a chronic cholestatic disorder, and SAMe were able to raise nuclear Nrf2 level, block the increase in MafG and c-Maf expression, protect against the fall in expression of GSH synthetic enzymes and GSH levels in these models [90,136]

In a burn rat model, intraperitoneal injection of glycine supplementation alleviated severe burn-induced cardiac injury by improving cardiomyocyte energy metabolism and increasing ATP and GSH contents [108]

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Sun Damage- Sun damage results from prolonged exposure to harmful UV rays, leading to premature aging, pigmentation changes, and an increased risk of skin cancer