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Despite all this evidence suggesting that disruption of protein homeostasis may impair interneuronal communication, the specific mechanisms linking ATXN3 to these effects remain to be investigated

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The next day, the wells were blocked for 1 h (4% bovine serum albumin (BSA), 5% sucrose in phosphate-buffered saline (PBS)), and then 100 L of sample was added and incubated for 12 h

This leads to the vicious cycle of an impingement syndrome

For seniors, symptoms can include anemia, memory difficulties and trouble with walking, Silverstein said