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The mechanism of EtOH-induced depletion of GSH may involve the direct conjugation of GSH with acetaldehyde (AcH), the reactive intermediate of EtOH oxidation [48, 49]

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Ezike TC, Okpala US, Onoja UL, Nwike PC, Ezeako EC, Okpara JO, Okoroafor CC, Eze SC, Kalu OL, Odoh EC, Nwadike U, Ogbodo JO, Umeh BU, Ossai EC, Nwanguma BC (2023) Advances in drug delivery systems, challenges and future directions

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To systematically understand tumor evolution toward adaptive resistance following immunotherapy, this section employs the cancer-immunity cycle framework, a concept proposed by Ira Mellman and Daniel S