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The p53/p21 and p16/Rb (retinoblastoma) axes are the two central signaling pathways involved in senescence regulation

[208] supported these findings to show that myocytic AR had limited effect on lean or fat mass between 5 and 30 weeks of age in male mice yet was involved in the transcription of genes related to polyamine biosynthesis and oxidative metabolism

Diehl SR, Boehnke M, Erickson RP, Ploughman LM, Seiler KA, Lieberman JL, et al

Antioxidants 11 (11), 2237

Finzi S, Li Y, Mitchell TN, Farr A, Maumenee IH, Sallum JM, Sundin O
