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Since GSSG is not readily exported out of mitochondria (Olafsdottir and Reed, 1988
At the same time, ROS generated by AgNPs create oxidative DNA lesions, with eight-oxoguanine being the most prominent

The safety, tolerability and efficacy of NouvNeu001 for Parkinsons disease (ClinicalTrials.gov) Available at: .Accessed 2 Aug

This process was impaired during aging due to a decreased localization of nNOS at the nuclear level [45]