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Description
Because B12 absorption declines with age, stress, gut issues, and certain medications, injections are often recommended when oral supplementation is no longer effective

A Systematic Review
The injection provider can administer the B12 shot deep into the muscle (intramuscularly) or into the tissue layer between the skin and the muscle (subcutaneously)
For instance, it serves as a treatment for pernicious anemia

The needle is inserted at a 90-degree angle, deep into the muscular tissue
