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Enhanced expression of epithelial -defensins

ECs sense shear stress (resulting from flow) through adhesive protein activation, glycocalyx elongation, bending of primary cilia, caveolae-mediated regulation of Ca+, ion channel activation, G protein-coupled receptor activation, and tyrosine kinase receptor activation 25,26

Preclinical work points to a mechanism centered on 3-adrenergic receptor modulation, enhanced lipolysis, and reduced lipogenesis, largely independent of the insulin- and IGF-1-related pathways associated with full-length HGH

Fibroblasts are cells that produce connective tissue components and other molecules