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While CoQ 10 decreased by 40% in elders, the combined supplementation of CoQ 10, acetyl-L-carnitine, and omega-3 fatty acids in 106 patients with early age-related macular degeneration improved visual functions and stabilized fundus alterations in an RCT [190,191]

Development and validation of response biomarkers would support evidence-based patient selection, optimizing outcomes while minimizing treatment of unlikely responders

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