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Its nine-amino-acid sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) and the unusual presence of a phosphorylated serine residue have made it a persistent subject of interest in neuropeptide and chronobiology research

Age-related changes in renal function, hepatic metabolism, and tissue perfusion theoretically could influence peptide clearance and distribution, though no studies have systematically examined age effects

J Physiol Pharmacol 2011

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