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Description
Some can be removed surgically

Second, heterogeneity in topical hypotensive therapy (various drug classes and preservative status) introduces uncontrolled confounding

Solana R, Tarazona R, Gayoso I, Lesur O, Dupuis G, Fulop T (2012) Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

New England Journal of Medicine, 318(26), 1720-1728

None of it is from a controlled trial, and the "week" structure below reflects how community sources tend to organize their anecdotes, not a validated schedule
