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Elmn, J

It can reduce hyperpigmentation, dark spots, and uneven skin tone, while also promoting cell regeneration and fighting oxidative stress

Indeed, when 2-DG and metformin simultaneously target glycolysis and mitochondrial complex I, T cell metabolism is normalized and lupus disease is reduced in mice, thus highlighting the importance of both glycolysis and mitochondrial metabolism in T cell function and autoimmune diseases (74, 76)

Among the mechanisms envisaged to occur to explain their toxicity against cells in culture are the release of toxic cadmium ions through their dissolution by the acidic environment of cell lysosomes [195] and their ability to generate and trap free radicals [196,197,198,199]

doi: 10.3390/cells10113145 68 BelfioreA