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Endosomal escape LNPs primarily enter cells through lectin- or caveolae-mediated endocytosis, facilitated by receptor-ligand interactions or non-specific adsorption [186]

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doi: 10.1038/s12276-023-01013-0 86 CroizerHMhaidlyRKiefferYGentricGDjerroudiLLeclereRet al

This relationship is being studied in aging, cardiac injury, metabolic disease, and heart failure

The promotion of ferritinophagy by NCOA4 has been confirmed in diseases such as diabetic complications, sepsis, Parkinsons disease, acute kidney injury, cerebral ischemiareperfusion injury and osteoarthritis 75,76,77,78,79,80,81