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Maybe, but what about the paper entitled, Vitamin B-12 Induced Acne

Accessed August 14, 2025

At the same time, it was agreed that symptoms affecting the central nervous system (mental function and neurological function), followed by those affecting the peripheral nervous system, are the most difficult symptoms to link to B12 deficiency (Figure 1), suggesting the need for more specific awareness in a primary medical care setting and an improvement in examination options

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It is a useful reminder to consider vitamin B12 deficiency in people taking metformin who have megaloblastic anaemia, neuropathy or other symptoms suggestive of deficiency
