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Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI

However, superoxide may influence the activities of proteins that contain the [FeS] clusters that mediate the regulation of DNA demethylation in a manner that is regulated by ascorbate

Several research studies have shown that oxidative stress is involved in the misfolding and accumulation of mutant huntingtin protein, which induces proteotoxicity and impairs oxidative metabolism, leading to neuronal damage and death 39 , 40

Yan N, Xu Z, Qu C, Zhang J

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