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Description
Recent Initiatives 9.3

Discovery of PIPE-359, a brain-penetrant, selective M(1) receptor antagonist with robust efficacy in murine MOG-EAE
Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model

In plain words, it may move the balance toward make more, break less, depending on the setting and the dose

et al., 2022
