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This pathology can subsequently propagate to the central nervous system via the vagus nerve, potentially triggering PD [34]

30 Among the pathways activated by IR and IGF-1R signaling are the RASRAFMEK1/2extracellular signal-regulated kinase (ERK)-1/2 pathway 34 and the phosphatidylinositol-3-kinase (PI3K)AKTmammalian target of rapamycin (mTOR) pathway, two fundamental pathways for tumor cell proliferation and survival (Figure 2)

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The gastrointestinal side effects at higher doses are too significant for most people to tolerate without a gradual buildup period