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Two primary areas emerge from the data as being critical for longevity: gut barrier integrity and metabolic function, especially as it relates to GLP-1

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These metabolites, including acetic acid, lactic acid, formic acid, and other SCFAs, reduce intracellular pH, creating an acidic microenvironment that is hostile to pathogen growth and proliferation (196)

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Rawat, Shalini et al (2022) RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes