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In conclusion, a therapeutic approach to IVD degeneration involving enhanced tissue repair by exogenous growth factors may be clinically important, but more research is needed to address the efficacy, duration of action, safety, and adverse effects of the growth factors administered in vivo

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As such, due to the multifaceted nature of chronic wound pathogenesis and susceptibility to abnormalities in ROS balance, interest in the role of ROS in wound healing, as well as the potential applicability of targeting ROS therapeutically, has grown significantly in recent years 14

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