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Their effects are marked by increased satiety, reduced appetite, and improved metabolic biomarkers, with a safety profile dominated by mild to moderate gastrointestinal adverse events

Dong H, Toyoda N, Yoneyama H, Kurachi M, Kasahara T, Kobayashi Y, Inadera H, Hashimoto SI, Matsushima K (2002) Gene expression profile analysis of the mouse liver during bacteria-induced fulminant hepatitis by a cDNA microarray system

M., DeOcesano-Pereira, C., Teixeira, C., & Moreira, V

Completion of adequate clinical trials will eventually make this determination

In fact, periodic breaks may enhance subsequent responsiveness by allowing receptor upregulation during the rest period