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A similar theoretical concern was raised about human growth hormone therapy more than 40 years ago

Fricke K
The 500-Dalton Ceiling Intact human skin allows passive transepidermal absorption of molecules under approximately 500 daltons

Indeed, P-15 was found to stimulate the proliferation and differentiation rate as well as the growth factor production of osteoblasts in vitro [113, 137, 189]

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