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doi: 10.1016/j.neubiorev.2019.01.003
As cartilage deteriorates, disruptions in extracellular matrix (ECM) homeostasissuch as depletion of proteoglycans, abnormal chondrocyte proliferation, and increased catabolic signalingfurther destabilize the disc-bone interface, leading to additional degenerative changes (26)
Ta NN, Schuyler CA, Li Y, Lopes-Virella MF, Huang Y (2011) DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice
doi: 10.1016/j.cell.2005.06.040
Manufactured without eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, corn and gluten
