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The CEDIM trial was a randomized, double-blind, placebo-controlled, multicenter trial in which 472 patients with acute myocardial infarction and high-quality two-dimensional echocardiograms received either placebo (239 patients) or L-carnitine (233 patients) within 24 hours of chest pain onset

It is most concentrated in tissues that use fatty acids as their primary fuel, such as skeletal and cardiac muscle

[DOI] [PubMed] [Google Scholar] 59.Hughes V.A., Frontera W.R., Wood M., Evans W.J., Dallal G.E., Roubenoff R., Fiatarone Singh M.A

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These processes involve the activation of muscarinic cholinergic receptors in the forebrain, and an increased expression of type-2 metabotropic glutamate (mGlu2) receptors in dorsal root ganglia neurons