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mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Last Updated: 2026

Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus

They eventually lead to the accumulation of lipid peroxides without the reduction of GSH (Yang et al., 2014)

Further upstream, levels of the glycolytic metabolite fructose-6 phosphate increase, which increases flux through the hexosamine pathway, where fructose-6 phosphate is converted by the enzyme GFAT to UDP N -acetylglucosamine (UDP-GlcNAc)
