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In addition, chronic accumulation of fumarate by deletion of fumarate hydratase (FH) led to the formation of succinic GSH, a covalent adduct of fumarate and GSH, which correlated with persistent oxidative stress and cellular senescence in renal cells (121)
Among the mechanisms discussed for the translocation of LPS in metabolic diseases are (i) a leaky gut [146]
Additionally, PAD may stabilize OS and immunity in ROU rats by stimulating Nrf2/HO-1 signaling and inhibiting TLR4/NF-B signaling
