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Acetyl L-carnitine demonstrates superior evidence for AlzheimersAlzheimers disease and mild cognitive impairment (slowed cognitive decline), diabetic neuropathy (pain reduction and nerve function improvement), depression (particularly in elderly), and age-related fatigue, with adequate doses of 500-2,000mg daily often taken in morning doses due to potential alertness effects

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2021 Aug 14;13(8):e17176

Another strategy for both siRNAs and ASOs is conjugating them to carrier molecules such as peptides or nanoparticles