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Peer review Peer review information Communications Biology thanks Nik Georgopoulos and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

The peptide appears to interact with the dopaminergic and serotonergic systems, which may contribute to its effects on pain perception and mood

The cartilage particles were digested with collagenase type II (0.2% w/v in BM, Worthington Biochemical, Lakewood, NJ, United States) in a 37C shaker overnight

In GHRH knockout murine models, CJC-1295 administered daily was associated with normalization of body weight, bone growth (femur, tibia), and pituitary GH mRNA levels

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