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However, there is still a lack of research to solidify this drugs position in the treatment of IBD, especially after mixed results achieved in phase 3 study (LAUREL), where contrary to earlier findings, no significant differences were observed between etrolizumab maintenance treatment and placebo for the primary endpoint of remission [58]

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Eur J Vasc Endovasc Surg

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The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]