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10.1371/journal.pone.0121123 95 PishavarE.TrentiniM.ZanottiF.CamponogaraF.TiengoE.ZanollaI.et al (2022)

Primary prevention strategies for OA should target modifiable dietary risk factors that drive obesity and metabolic dysfunction, key contributors to disease onset
The same can be said about vitamin E and selenium

It acts as an inhibitor of nicotinamide N-methyltransferase (NNMT), a crucial enzyme involved in energy metabolism and fat storage

Prevention is always preferable to damage control
