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189 In an uncontrolled trial that included 119 men with idiopathic infertility, supplementation with a multi-nutrient cocktail containing vitamins, minerals, and several antioxidants twice daily for three months led to significant improvements in sperm concentration, motility, morphology, and DNA fragmentation compared with pretreatment analyses

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Endothelial cell dysfunction, which is characterized by impaired endothelium-dependent vasodilation due to the compromised ability of endothelial cells to produce NO, constitutes a major cause of cardiovascular diseases [59]