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Description
These data, together with mechanistic work showing that insulin stimulates VEGF and IGF production while glucose primes macrophages for inflammatory cytokine release 394 , suggest that the combination of high glucose and high insulin is more deleterious than hyperglycemia alone

Indeed, studies in both tumor cell lines and animals confirmed that a therapeutic advantage was obtainable with combinations of ethacrynic acid and alkylating agents (Tew et al , 1988

These investigations require an interdisciplinary approach, integrating knowledge and methodologies from chemistry, materials science, biology, and clinical medicine

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Pharmaceutics 15 (6), 1593
