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Secondly, motivated by the need for a more relevant measure of destructive brain pathology, AVONEX clinical trial investigators pre-specified brain atrophy as an exploratory measure, and applied a new highly precise measure of brain atrophy, the so-called brain parenchymal fraction, to images collected during the trial

Integrated platforms (e.g., brain organoids coupled with clinical cohorts) are needed to define therapeutic windows and contraindications