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Significant changes in TCA intermediates fumarate and succinate, and in the secondary TCA metabolites succinyl-carnitine and methyl succinyl-carnitine were observed, arguing that the potential anti-inflammatory properties of these metabolites are mediated by metabolic rewiring

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[DOI] [PubMed] [Google Scholar] 56.Bauer K.C., Littlejohn P.T., Ayala V., Creus-Cuadros A., Finlay B.B

Due to defective renal absorption (free) carnitine is excreted in the urine of patients with primary deficiency and can result in tissue carnitine levels dropping to below 10% of normal [14, 22, 2426]