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Preclinical studies of stem-cell based treatments for Parkinsons and disease modeling efforts iPSCs and 3D brain organoids have significantly advanced our understanding of PD pathophysiology and assisted in drug development by allowing us to replicate the specific mutations commonly found in familial PD (fPD), including those in -synuclein [74, 75]

doi: 10.1001/archinte.1996.00440060059007 555 OtsukaYEgawaKKanzakiNIzumoTRogiTShibataH

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